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KMID : 1094020130300010075
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Journal of Veterinary Clinics
2013 Volume.30 No. 1 p.75 ~ p.79
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Experimental Equine Laminitis Induced by Treatment with Oligofructose
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Kwon Mi-Young
Ryu Doug-Young
Jeon Hyung-Seon
Kim Joon-Gyu
Cui Feng-Ji
Lee Seung-Woo
Kim Yong-Baek
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Abstract
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Laminitis is a common horse disease that causes pain and disability. One of the major causes of laminitis is carbohydrate overload, which leads to the overgrowth of gram-positive bacteria and subsequent toxemia. This study was performed to establish an experimental model of acute phase laminitis. A horse was fed with a bolus dose of oligofructose, examined for clinical signs and blood parameters, and euthanized for necropsy and histopathology. After administration, the horse exhibited clinical signs including watery feces, inappetence, severe lameness, pyrexia and tachycardia. Complete blood count showed increased hematocrit, lymphocytosis and neutropenia. Serum chemistry revealed hyperglycemia, hyperproteinemia, high level of glutamic oxalate transaminase, creatinine, uric acid and mild hyponatremia. Histologically, the lamina tissue was edematous with mild infiltration of inflammatory cells. These findings indicate that oligofructose-induced laminitis in horse is an appropriate model for studying pathogenesis of acute phase laminitis.
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KEYWORD
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Equine laminitis, toxemia, oligofructose, complete blood count, serum chemistry
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